The study examined the role of resilience and Gender in predicting spirituality among Nigerian students. Two hundred and eighteen (218) students participated in the study. They included 93 males and 125 females aged 18-30 years (mean age: 21.90; std: 2.03). A mixed sampling design involving simple random and incidental samplings was used to select the departments and students that participated in the study. Two instruments (spirituality scale and resilience scale) and demography were used to collect data for the study. The study adopted a correlational design and simple linear regression statistics for data analysis. The result of the first finding showed that resilience positively correlated with spirituality but was not significant (r = .070, P<.153). The result further showed that resilience did not significantly predict spirituality (ß =.070, p = .313). The second finding revealed also that gender positively correlated with spirituality but was not significant(r = .011, P =.433 ). The result further showed that gender did not significantly predict spirituality (ß =.001, P = .984). This indicated that spirituality is culturally sensitive when it comes to gender and resilience. This cultural sensitivity may be the reason for the differences in findings between this present study and previous studies. The results may instigate understanding, planning and designing programmes for further studies in understanding spirituality.