This study investigated perceived transformational leadership and core self evaluations as predictors of safety compliance among health workers. Two hundred and fifty (250) health workers comprising one hundred and forty (140) males and one hundred and ten (110) females participated in this study. Participants were randomly selected from two government owned hospitals in Enugu State. Their ages ranged from 20 to 67 years with a mean age of (M = 36.70, SD = 7.91). The study was cross sectional in which core self evaluation scale, transformational leadership sub-scale of the adapted multifactor leadership questionnaire and compliance with safety behavior scale were administered for data collection. Hierarchical multiple regression was used for data analysis. The results indicated that transformational leadership was a significant positive predictor of safety compliance while core self evaluations was also a significant positive predictor of safety compliance among health workers. The implication and recommendations were further discussed.