The study examined the extent to which Perceived Stress predicted the Quality of life among undergraduate Students in University of Port Harcourt, Rivers State. The study adopted the cross-sectional research design. Primary data were collected through the administration of questionnaire on a sample of the study population. Purposive sampling technique was used to select the respondents comprising both males and females. Two standardized psychological instruments namely: The Perceived Stress Scale (PSS) and Quality of School Life (QSLQ) instrument were used to collect the data for the study. The data generated was subjected to linear and multiple regression analyses. The results revealed that there is negative significant relationship between perceived stress and quality of life (r = -.49, p<.01). The results further revealed that perceived stress significantly and independently predicts quality of life (β = -.49, t = -5.80, p<.05). The contribution of perceived stress in explaining the variance in quality of school life was 24% (R2= .24), and the model was significant, F(1, 108) = 33.66, p<.05. The study concluded that there was a significant negative influence of perceived stress on the quality of school life among students in University of Port Harcourt. Finally, it was concluded that higher level of perceived stress results to lower level of quality of school life.