This study examined the effects of gender, occupational level and industry type on the health status of employees in some Nigerian manufacturing industries. Data were collected from 600 employees sampled from shoe, textile and food industries. The sample included 150 junior workers (120 males and 30 females), 30 supervisors (27 males and 3 females) and 20 managers (18 males and 2 females) totaling 200 employees from each industry. The result of the t-statistics shows no significant gender difference in their health status. The result of the One-way ANOVA shows a significant difference due to occupational level. Moreover, the results of the Two-way (3 X 3) ANOVA show the significantly separate and interaction effects of occupational level and industry type on their health status. The results have implications for developing good health promotion programmes based on the needs of employees accordingly. The paper concludes by suggesting that work should be designed and organized to enhance the psychological well-being and health of workers in the future.