This study explored how parental stress, gender, and resilience played roles in parental mental wellbeing during the nationwide lockdown in Nigeria. Participants were parents, 118 (57.6%) females and 87 (42.4%) males who reside in Enugu, Southeast Nigeria. They were recruited online through social media platforms using Respondent-Driven Sampling (RDS) method. They responded to questions on socio-demographic information and measures of parental stress, resilience and mental wellbeing. Hayes' regression-based PROCESS macro was used to analyze the data. Parental stress was negatively associated with mental wellbeing, while resilience was positively associated with mental wellbeing. Gender was not independently significantly associated with mental wellbeing, but it moderated the relationship between resilience and mental wellbeing. The positive relationship between resilience and mental wellbeing was strongest for male parents than female parents. This study has brought to the fore the negative relationship between lockdown and parental stress and their effect on parental wellbeing.